A Mechano-Chemical Computational Model of Deep Vein Thrombosis

Computational models of deep vein thrombosis (DVT) typically account for either the mechanical or biochemical factors involved in thrombus formation. Developing a model that accounts both will improve our understanding coagulation process this particular disease. The work presented study details development CFD considers reactions between thrombin and fibrinogen, pulsatile blood flow, clot growth within three-dimensional patient-specific common femoral vein. Thrombin is released into bloodstream from an injury zone on wall Michaelis–Menten equation used to represent conversion fibrinogen fibrin, final product process. starts with two-dimensional idealized geometry. At stage, conduct parametric determine effects varying parameters such as inlet velocity, diameter, peak concentration size shape formed. Peak key factor driving initiation propagation clots To demonstrate potential use model, then extended image-derived Realistic was achieved using compared formed vivo . volume patient about 4% smaller than simulation. This demonstrates further refinement, could be interventional planning. provides means predicting formation under different physiological conditions non-invasive manner.